T Cell Lymphoblastic Lymphoma Showing Abberant Synaptophysin Expression in a Child

Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma

We describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lymphoma and was successfully treated with immunoglobulin and steroids. ITP is known to be associated w...

Prolonged Vincristine Toxicity Induced by Concurrent Posaconazole in a Child with T-cell Acute Lymphoblastic Leukemia

Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abiliti...

Altered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1).  HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...

18F-FDG PET/CT Images in a Child with Cutaneous B cell Lymphoblastic Lymphoma Presented with Bone Involvement

Abstract B-cell lymphoblastic lymphoma (B-LBL) is an uncommon subtype of pediatric non-Hodgkin Lymphoma (NHL) which rarely involves the skin primarily. The positron emission tomography with 2-deoxy-2-[fluorine- 18] fluoro-D: -glucose integrated with computed tomography (18F-FDG PET/CT) scan findings of a 8-year-old boy with cutaneous B-LBL were presented. PET/CT scan demonstrated mild FDG up...